According to the EFSA's Expert Panel on Food Additives and Flavorings 2021 opinion regarding titanium dioxide, it could not rule out a concern for genotoxicity from ingestion of the material based on a perceived gap in data on this risk, which serves as the basis for current ban, said a March report on the decision.
Titanium dioxide R-996 is mainly used in powder coatings, water-based and solvent-based external coatings, high-grade color masterbatches, plastics, rubber, inks, high-grade paper and wax paper and leather upholstery fabrics, cosmetics, suitable for high-grade interior coatings, high-solid paints, Road marking paints, marine paints and inks, and also used in the plastics, rubber, paper and leather industries.
A legal additive in the United States, titanium dioxide is used in everything from food to consumer goods and the U.S. Food and Drug Administration says regulated use of the product as a color additive in food is safe within certain restrictions.


The global Lithopone market size was valued at $169.8 million in 2019, and is projected to reach $218.6 million by 2027, growing at a CAGR of 3.3% from 2020 to 2027.
All About Titanium Dioxide Pigment
In conclusion, navigating the wholesale lithopone pigment pricelist requires a comprehensive understanding of various influencing factors, including grade differences, sourcing locations, quality considerations, market dynamics, and global trends. By staying informed and strategically analyzing these elements, businesses can make educated purchasing decisions that enhance their competitiveness and profitability in the ever-evolving market of pigments.
Overwhelmingly, research that’s relevant to human eating patterns shows us that E171 is safe when ingested normally through foods and drugs (1,2).
Tio2 Powder CR-930 Titanium Dioxide Free Sample
Asia-Pacific accounted for the largest revenue share in 2019. China and India are the key markets in the region that have a growing paint and plastics industry, owing to rise in urbanization and industrial developments such as in automotive and construction domains.
Does Titanium Dioxide Cause Cancer?
A Lawsuit Claims Skittles Are Unfit for Consumption. Experts Weigh in, by Rachel Rabkin Peachman, The New York Times, July 26, 2022
Wholesale Dio2 Cas 13463-67-7


For the First Quarter of 2022
In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2. With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”